Patti M. Marxsen's articles, essays, poetry, and reviews have appeared in over 40 journals and magazines in the USA, Switzerland, and France, including Caribbean Writer, Ekphrasis, Fourth Genre, The International Herald Tribune, Journal of Haitian Studies, Offshoots: Writing from Geneva, Prairie Schooner, Saisons d'Alsace, Women's Review of Books, and The Writer. Among her writings, Marxsen has been active in the field of Haitian Studies and also authored two articles on C.F. Ramuz in The French Review (2008) and Absinthe: New European Writing (2009). Her books include a collection of travel essays—Island Journeys: Exploring the Legacy of France (Alondra Press, 2008), which was a finalist for the Non-Fiction Book Award of the Writers League of Texas. She has also published a collection of short fiction—Tales from the Heart of Haiti, which was a finalist for the 2008 Paris Prize for Fiction before it was published by Educa Vision Inc. of Miami, Florida (2010).
Marxsen's work in Schweitzer Studies has been noteworthy. Her translation from the French of Albert Schweitzer's Lambarene: A Legacy of Humanity for Our World Today by Jo and Walter Munz appeared in 2010. More recently, her carefully-researched biography of Albert Schweitzer's wife, Helene Schweitzer: A Life of Her Own, will be published by Syracuse University Press in 2015.
She has twice been nominated for a Pushcart Prize and achieved a Special Mention in the 2009 Pushcart Anthology with her travel essay, "Alone in Amsterdam." Another travel essay, "Gâteau de Payerne," won the Geneva Writers Literary Award for Non-Fiction in 2013. Patti Marxsen lives in Switzerland and travels frequently to Maine.

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